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Elisabetta Verderio Edwards

Elisabetta Verderio Edwards

Professor

School of Science & Technology

Staff Group(s)
Bioscience

Role

Dr Verderio Edwards is:

  • Professor of Biochemistry
  • Academic Coordinator for Research Excellence Framework 2029 (Allied Health Professions, Dentistry, Nursing and Pharmacy)
  • Member of SHiMR steering committee
  • Director of study for PhD projects, MRes/MSc projects and Erasmus/international placements
  • Mentor of post-doctoral fellows (Marie Skłodowska-Curie Actions MSCA projects on request).

Visit  the EX-CELL Verderio Edwards Lab website.

Research areas

The extracellular environment and the cross-talk between the ECM (extracellular matrix) and extracellular vesicles as matrix and cell messengers.

The extracellular function of Transglutaminase-2 (TG2) in cell-matrix dynamics and the relationship of this with wound healing, tissue fibrosis and aging.

Extracellular vesicles proteomics/transcriptomics to track disease progression and therapeutic applications of mesenchymal/stromal stem cells extracellular vesicles.

Collaborators

Internationally much research has been conducted with CNRS- Grenoble Institut de Biologie Structurale, Grenoble (Prof H. Lortat-Jacob), University of Bologna, Department of Biological Sciences (Prof D. Serafini-Fracassini and Prof S. Del Duca), CNR Institute of Neuroscience in Milan (Dr C Verderio), University of Messina (Prof Daniela Caccamo), University of Campania, Precision Medicine (Prof M Caraglia), University of Patras, Department of Nephrology and Renal Transplantation (Prof Dimitris S Goumenos).

In the United Kingdom, a long term collaboration has been with the University of Sheffield, School of Medicine and Biomedical Sciences (Prof Tim Jonson and Dr Phil Watson) and with Prof Dave Abraham, Institute of Immunity and Transplantation, at University College London (UCL).

PhD Projects available in the following areas:

  • Extracellular vesicles -cell and -ECM dynamics
  • Mesenchymal Stem Cells extracellular vesicles in neuronal cell survival
  • Extracellular transglutaminase-2 in aging, neurodegeneration and fibrosis
  • Urinary extracellular vesicles proteomics/transcriptomics and markers of CKD progression

The range of skills I have learned in 6 months from the start of my PhD are amazing. (First Year PhD Student)

The level of guidance and feedback I have received throughout my PhD studies was continuous and of high standard. (Final Year PhD student)

For more information email: elisabetta.verderio-edwards@ntu.ac.uk

Opportunities to carry out postgraduate research towards an MPhil / PhD exist in all the areas identified above and further information may be obtained from the https://www.ntu.ac.uk/research/research-degrees-at-ntu.

External activity

Sponsors and collaborators

  • UCB Pharmaceuticals
  • Mestag Therapeutics
  • Chiesi Pharmaceutics
  • BBSRC
  • Eranda Rothschild
  • Tony Marmont foundation
  • Kidney Research
  • Wellcome Trust
  • iNET East Midlands
  • British Council-CRUI
  • EPSRC
  • VU Medical School Amsterdam
  • CNR Institute, Milan
  • FEBS
  • Biochemical Society
  • University of Bologna

Publications

Extracellular transglutaminase-2, nude or associated with astrocytic extracellular vesicles, modulates neuronal calcium homeostasis. Tonoli, E., Verduci, I., Gabrielli, M., Prada, I., Forcaia, G., Coveney, C., Savoca, M., Boocock, D.J., Sancini, G., Mazzanti, M., Verderio, C., and Verderio, E.A.M. Prog Neurobiol. 2022, 216:10231.

Proteomic Profiling Reveals the Transglutaminase-2 Externalization Pathway in Kidneys after Unilateral Ureteric Obstruction. Furini, G., Schroeder, N., Huang, L., Boocock, D., Scarpellini, A., Coveney, C., Tonoli, E., Ramaswamy, R., Ball, G., Verderio, C., Johnson, T.S., Verderio, E.A.M. Journal of the American Society of Nephrology. 2018, 29:880-905.

Interplay between transglutaminases and heparan sulphate in progressive renal scarring. Burhan, I., Furini, G., Lortat-Jacob, H., Atobatele, A.G., Scarpellini, A., Schroeder, N., Atkinson, J., Maamra, M., Nutter, F.H., Watson, P., Vinciguerra, M., Johnson, T.S, Verderio, E. Scientific Reports. 2016, 6:31343.

Syndecan-4 knockout leads to reduced extracellular transglutaminase-2 and protects against tubulointerstitial fibrosis. Scarpellini A, Huang L, Burhan I, Schroeder N, Funck M, Johnson TS, Verderio EA. Journal of the American Society of Nephrology. 2014, 25:1013-27.

Transglutaminase-2 interaction with heparin: identification of a heparin binding site that regulates cell adhesion to fibronectin-transglutaminase-2 matrix. Lortat-Jacob H, Burhan I, Scarpellini A, Thomas A, Imberty A, Vivès RR, Johnson T, Gutierrez A, Verderio E, Journal of Biological Chemistry, 2012, 287:18005-18017

A crucial sequence for transglutaminase type 2 extracellular trafficking in renal tubular epithelial cells lies in its N-terminal -sandwich domain. Chou CY, Streets AJ, Watson PF, Huang L, Verderio E, Johnson TS, Journal of Biological Chemistry, 2011, 286:27825-27835

Simulated environmental criticalities affect transglutaminase of Malus and Corylus pollens having different allergenic potential. Iorio RA, Di Sandro A, Paris R, Pagliarani G, Tartarini S,  Ricci G,  Serafini-Fracassini D, Verderio E, Del Duca S, Amino Acids, 2011, 42:1007

An extracellular transglutaminase is required in apple pollen tube growth. Di Sandro A, Del Duca, S, Verderio E, Hargreaves A, Bonner P, Griffin M, Iorio R, Scarpellini A, Serafini-Fracassini D, Biochemical Journal, 2010, 429: 261-271

Heparan sulphate proteoglycans are receptors for the cell-surface trafficking and biological activity of transglutaminase-2. Scarpellini A, Germack R, Lortat-Jacob H, Muramatsu T, Billett E, Johnson T, Verderio E, Journal of Biological Chemistry, 2009, 284:18411-1842

Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta(1) integrin co-signaling. Telci D, Wang Z, Li X, Verderio EA, Humphries MJ, Baccarini M, Basaga H, Griffin M, Journal of Biological Chemistry, 2008, 283:20937-41

See all of Elisabetta Verderio Edwards's publications.

See all of Elisabetta Verderio Edwards's publications...

Press expertise

  • Chronic kidney disease
  • Fibrosis
  • Wound healing
  • Aging
  • Transglutaminase type 2 (TG2)
  • Extracellular vesicles